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Studies indicate that skeletal muscle possesses the complete enzymatic machinery necessary to convert DHEA into testosterone and estradiol, including 3-hydroxysteroid dehydrogenase, 17-hydroxysteroid dehydrogenase, and aromatase enzymes

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Combining approaches often produces better results than any single method

As a representative molecule of NAMPs/DAMPs/PAMPs, the nuclear protein high-mobility group box protein 1 (HMGB1) plays an important role in CNS-related pathologies by being released from damaged cells 24